amiodarone induced hypothyroidism
Amiodarone can lead to hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormones. This effect is primarily due to the high iodine content in amiodarone, as well as its long half-life in the body.
### Mechanism:
1. **Iodine Load**: Amiodarone contains a significant amount of iodine, which can lead to alterations in thyroid hormone synthesis. In patients who are vulnerable or have pre-existing thyroid disease, this can result in decreased thyroid hormone production.
2. **Autoimmune Reaction**: Amiodarone can trigger autoimmune thyroiditis in some individuals, where the immune system attacks the thyroid gland, leading to decreased hormone production.
### Symptoms of Hypothyroidism:
Common symptoms of hypothyroidism include:
- Fatigue
- Weight gain
- Cold intolerance
- Depression
- Dry skin
- Hair loss
- Constipation
### Monitoring and Management:
- **Regular Monitoring**: Patients on amiodarone should have their thyroid function tested regularly, including measurements of TSH (Thyroid Stimulating Hormone) and free T4 levels.
- **Treatment**: If hypothyroidism develops, it is typically treated with levothyroxine, a synthetic form of thyroid hormone.
- Pendred syndrome
- APS stands for Autoimmune Polyglandular Syndrome
- Destructive thyroiditis
- AFTN
- Nonthyroidal illness
- Gestational transient thyrotoxicosis
- The rate-limiting step in thyroid hormone biosynthesis
- McCune-Albright syndrome
- TSH suppression therapy
- Teprotumab,anti-IGFR-1R
- Maternal thyroid function
- The ideal TSH level for IVF treatment
- Complications of Graves' Disease in Pregnancy
- Postpartum thyroiditis
- Amiodarone-induced thyroiditis
- Adenomatous goiter
- Amiodarone can lead to hypothyroidism